Torsade de Pointes due to Methadone Use in a Patient with HIV and Hepatitis C Coinfection
نویسندگان
چکیده
We present a case of Torsade de Pointes secondary to multiple factors including patient susceptibility and iatrogenic influences. Contributing causes are presented, and the approach to treatment is discussed.
منابع مشابه
Torsade de pointes caused by polypharmacy and substance abuse in a patient with human immunodeficiency virus
Drug-induced QT prolongation is a potentially dangerous adverse effect of some medication combinations. When QT prolongation progresses to torsade de pointes, life-threatening or fatal outcomes may result. A 57-year-old man with a history of human immunodeficiency syndrome on abacavir, nevirapine, tenofovir, voriconazole, and methadone presented to the emergency department with a chief complain...
متن کاملAn Analysis of Registry Data
Results: 1646 cases of ventricular arrhythmia or cardiac arrest and 379 cases of QTc prolongation or torsade de pointes were associated with methadone. Monthly reports of QTc prolongation or torsade de pointes increased from a mean of 0.3 (95% CI, 0.1 to 0.5) before the 2002 publication to a mean of 3.5 (CI, 2.5 to 4.8) after it. After 2000, methadone was the second-most common primary suspect ...
متن کاملPoly Pharmacy-Induced Long-QT Syndrome and Torsades de Pointes: A Case Report
Polypharmacy-induced QT prolongation is a possible hazardous adverse effect of several medication combinations. When QT prolongation leads to torsade de pointes, life-threatening or mortal outcomes can result. A 45-year-old man presented to the emergency department due to the use of methadone in the field with ventricular tachycardia and after successful resuscitation after cardiac arrest, unde...
متن کاملTorsade de pointes associated with very-high-dose methadone.
BACKGROUND Methadone is an effective treatment for opioid dependency and chronic pain. A methadone derivative, levacetylmethadol, was withdrawn from the European market after being associated with torsade de pointes. To date, no association between methadone and this arrhythmia has been described. OBJECTIVE To evaluate a series of methadone-treated patients experiencing torsade de pointes. ...
متن کاملItraconazole-induced torsade de pointes in a patient receiving methadone substitution therapy.
ISSUES Methadone, a pharmacological agent used to treat heroin dependence is relatively safe, but may cause cardiac arrhythmias in the concurrent presence of other risk factors. APPROACH AND KEY FINDINGS: This case report highlights the risk of torsade de pointes, a life-threatening cardiac arrhythmia, in a heroin-dependent patient receiving methadone substitution therapy who was prescribed itr...
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ورودعنوان ژورنال:
دوره 2010 شماره
صفحات -
تاریخ انتشار 2010